Pheochromocytoma is a tricky disease to diagnose. Diagnostic techniques for pheochromocytoma include:

• Biochemical tests for hormones, including dopamine, metanephrines, and normetanephrines.  Interpretation of the test results requires considerable experience, and both false negative and false positive results are common.
• Standard imaging with CT/MRI may help localize the tumor
• Imaging with MIBG or PET may also help identify the primary tumor and metastases.
• Biopsy of a pheochromocytoma can be dangerous, since this can precipitate hormonal symptoms. A decision to biopsy should only be made with the input of an experienced medical team.