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Caring for Carcinoid Foundation


Trial Title: A Biological Study of Resveratrol's Effects on Notch-1 Signaling in Subjects With Low Grade Gastrointestinal Tumors
ID Number: NCT01476592
Status: Enrolling
Principle: Emily R. Winslow, MD
Conditions: Neuroendocrine Tumor
Ages Eligible for Study:18 Years and older
Genders Eligible for Study:Both
Accepts Healthy Volunteers:No

Inclusion Criteria:

  1. ECOG performance status of 0-2
  2. Age >18 years old
  3. Women who are not postmenopausal must have a negative enrollment blood test and agree to use an effective mode of contraception while taking the study medication
  4. Greater than four weeks must have elapsed since any previous therapy was administered for the neuroendocrine tumor, including surgery, radiation, chemotherapy or local liver therapy.
  5. Octreotide use is allowed but must be initiated at least four weeks prior to enrollment and to the pre-treatment biopsy
  6. Able to give informed consent and willing to undergo the post-treatment research biopsy
  7. Must be able to take oral medications and be without GI tract obstructive symptoms
  8. Subjects with another malignancy for which they are either undergoing treatment with chemotherapy or radiation, or with a malignancy for which such treatments have been recommended, would be excluded or withdrawn from the study.
  9. Must agree to abstain from excessive alcohol, as defined by greater than the equivalent of three glasses of wine per day or one six pack of beer per day

Exclusion Criteria:

1. The principal investigator will review each subject's current medications prior to enrollment of the study to ensure that the administration of Resveratrol will not affect their current medications.

Location: University of Wisconsin-Madison

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