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Dave, Suzi, and Lauren at 2011 Focus on Neuroendocrine Tumors Conference in Philadelphia, PA

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CFCF Awards New Research Grant to Dr. Eric Nakakura

Wednesday, December 12, 2012

The Caring for Carcinoid Foundation is pleased to announce the latest grant award through our grant-making partnership with the American Association for Cancer Research to Eric Nakakura from the University of California, San Francisco to overcome resistance to mTOR inhibition in pancreatic neuroendocrine tumor patients. 

The mammalian target of rapamycin (mTOR) is a protein involved in many cellular pathways including cell growth and death.  In neuroendocrine tumors, mTOR can become disregulated and consequently promote tumor cell growth. CFCF-funded scientists at Johns Hopkins University identified mutations in the mTOR signaling pathway among patients with non-functioning pancreatic neuroendocrine tumors (Jiao, 2011).

Oncolytic Virus Therapy

Monday, November 12, 2012

An oncolytic virus is a virus that preferentially infects and destroys cancer cells.  Oncolytic viruses are an attractive, potential approach to cancer therapy because of their ability to seek out cancer cells.  These viruses can be used to either directly destroy cancer cells or inject desired materials into a cancer cell. An oncolytic virus can be engineered in the laboratory or can occur naturally.  At this time there are no oncolytic viruses approved by the US FDA to treat cancer patients. 

There has been recent buzz in the neuroendocrine tumor community about an oncolytic virus to treat neuroendocrine tumors. We welcome this publicity as an opportunity to raise awareness about neuroendocrine tumors.  In particular, for increased funding for scientific research to develop effective therapies for patients.

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